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An artificial intelligence system for the diagnosis and risk stratification of chronic atrophic gastritis under white light endoscopy

Revolutionizing gastric cancer diagnostics through advanced data analysis and expert collaboration.

Innovative AI for Endoscopy Insights

At Gastrolume AI, we enhance endoscopic diagnosis through advanced data analysis and expert collaboration, ensuring accurate staging and improved patient outcomes in gastric health.

Two hands wearing pink gloves are performing a procedure or examination on the neck area of a person lying back. The person wears a grey top, and there is a white pad placed on their chest. The gloved hands focus on a small area at the base of the neck.
Two hands wearing pink gloves are performing a procedure or examination on the neck area of a person lying back. The person wears a grey top, and there is a white pad placed on their chest. The gloved hands focus on a small area at the base of the neck.

Advanced Endoscopy Solutions

Innovative AI-driven diagnostic services for enhanced endoscopy and pathology analysis.

Data Annotation Experts

We meticulously annotate endoscopy reports and pathology descriptions for precise staging and grading.

A circular microscopic view showing a tissue sample, characterized by a complex pattern of cell structures in various shades of purple and pink against a dark background.
A circular microscopic view showing a tissue sample, characterized by a complex pattern of cell structures in various shades of purple and pink against a dark background.
AI Retrieval Systems

Utilizing advanced vector retrieval to enhance diagnosis through similar-case analysis and guideline integration.

A hospital hallway is depicted with a gurney positioned in the foreground. The corridor is clean and well-lit, with signs indicating different departments such as 'GASTROENTEROLOGIE.' Several closed doors and white walls line the hallway, creating a sterile and orderly environment.
A hospital hallway is depicted with a gurney positioned in the foreground. The corridor is clean and well-lit, with signs indicating different departments such as 'GASTROENTEROLOGIE.' Several closed doors and white walls line the hallway, creating a sterile and orderly environment.

Endoscopy Insights

Comprehensive analysis through structured data and expert annotations.

A healthcare professional wearing a red surgical cap, mask, and gloves is performing an intricate procedure. The person is using surgical tools and wearing specialized binoculars to enhance vision. The setting appears to be a brightly lit operating room.
A healthcare professional wearing a red surgical cap, mask, and gloves is performing an intricate procedure. The person is using surgical tools and wearing specialized binoculars to enhance vision. The setting appears to be a brightly lit operating room.
Phase One

Data collection and expert annotation of endoscopy reports.

A medical professional wearing protective gear and magnifying glasses is performing a procedure. The setting is brightly lit, highlighting the focus on the detailed work being done. Instruments and gloved hands are visible, indicating a clinical environment.
A medical professional wearing protective gear and magnifying glasses is performing a procedure. The setting is brightly lit, highlighting the focus on the detailed work being done. Instruments and gloved hands are visible, indicating a clinical environment.
A close-up image of a dental examination taking place. A dentist wearing gloves is using dental tools inside a patient's mouth to inspect or treat the teeth.
A close-up image of a dental examination taking place. A dentist wearing gloves is using dental tools inside a patient's mouth to inspect or treat the teeth.
A medical imaging device with a monitor displaying a user interface featuring multiple icons and buttons. The device is labeled 3D OCT Maestro by Topcon. There is also a black adjustable arm and other medical supplies in the background.
A medical imaging device with a monitor displaying a user interface featuring multiple icons and buttons. The device is labeled 3D OCT Maestro by Topcon. There is also a black adjustable arm and other medical supplies in the background.
Phase Two

Prompt engineering and retrieval for diagnostic suggestions enhancement.

Chronic atrophic gastritis (CAG) is a key precancerous lesion for gastric cancer; its early detection and precise risk stratification are critical for improving patient survival and reducing healthcare costs. Traditional diagnosis depends on endoscopists’ experience and pathology, which are subjective, time-consuming, and limited in accessibility. Therefore, our central research question is: Can a fine-tuned GPT-4 model deeply integrate white-light endoscopy image reports, pathological descriptions, and clinical indicators (e.g., H. pylori status, gastric acidity) to automatically generate medically interpretable CAG diagnostic conclusions and risk stratification recommendations?

Sub-questions include:

Multimodal Feature Extraction: How to engineer prompts that extract key features from endoscopy descriptions, pathology reports, and clinical data?

Staging Determination: Can the model accurately classify CAG into mild, moderate, and severe stages based on distribution of atrophy and intestinal metaplasia, aligned with OLGA/OLGIM staging systems?

Cancer-Risk Prediction: Integrating age, family history, and pathology dysplasia grades, can GPT-4 output five-year probabilities of progression from CAG to gastric cancer?

Explainability & Consistency: Does the model’s output include clear causal reasoning chains that both endoscopists and pathologists can review and reach high agreement?

We hypothesize that combining retrieval-augmented generation with GPT-4 fine-tuning will achieve ≥88% accuracy in staging, a risk-prediction AUC ≥0.85, and explanation coherence agreement ≥0.9 among clinicians.

Two surgeons wearing blue surgical gowns and caps perform an operation under bright surgical lights. Medical equipment and monitors surround them in a sterile operating room environment.
Two surgeons wearing blue surgical gowns and caps perform an operation under bright surgical lights. Medical equipment and monitors surround them in a sterile operating room environment.
Research

Innovative study on endoscopy and pathology insights.

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